The desire of the ITX form factor is usually it's incredibly small size. Switching to an ITX sized motherboard can save you a lot of space and allow you to pack your computer into a very small and space saving case. With the right motherboard choice, you can even do the switch without losing any performance or functionality compared to mATX or full ATX systems - except for a few slots. ITX boards only have one expansion slot, meaning you can't run anything more than a single graphics card. Although you can still put a really high performing graphics card in the system to make a great gaming rig, the absence of any additional slots means that you could never upgrade to a dual graphics card setup, or add any other expansion cards that may be needed.
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